Lazy Leukocyte Syndrome

Leukocyte adhesion deficiency syndrome: a controversy solved.

Sadly, mistakes of nature are often our greatest learning tools. Such is the case with the recent description by three independent groups of the molecular etiology of leukocyte adhesion deficiency (LAD) syndrome III.1–3 The discovery that mutations in kindlin-3 are responsible for this rare genetic disorder teaches us a great deal about how leukocytes regulate adhesion and trafficking through t...

Lazy leucocyte syndrome--disorder of the granulocyte membrane?

An adult with long-standing neutropenia had the functional granulocyte abnormalities typical of the lazy leucocyte syndrome. Scanning electron microscopy of the patient's neutrophils showed alteration in the surface configuration of the cell with coarsening of the normal fine ruffles and the appearance of knob-like projections. Similar functional and anatomical changes were induced in normal ne...

Lazy Learners at work : the Lazy Learning

Package ‘ lazy ’

Description By combining constant, linear, and quadratic local models, lazy estimates the value of an unknown multivariate function on the basis of a set of possibly noisy samples of the function itself. This implementation of lazy learning automatically adjusts the bandwidth on a query-by-query basis through a leave-one-out cross-validation.

Lazy Acquisition

Assume your company is doing cutting-edge software development and therefore it always has a look at the latest technology specifications. One day your boss comes to you and asks you: “Michael, did you hear about this new CORBA Component Model technology.” You say: “Of course, I read the specification several times.” Saying this was a fault, you are now responsible for being one of the first to...